High Doses of Vitamin D May Cut Pregnancy Risks

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May 4, 2010 — Women who take high doses of vitamin D during pregnancy havea greatly reduced risk of complications, including gestational diabetes,preterm birth, and infection, new research suggests.

Based on the findings, study researchers are recommending that pregnantwomen take 4,000 international units (IU) of vitamin D every day — at least 10times the amount recommended by various health groups.

Women in the study who took 4,000 IU of the vitamin daily in their secondand third trimesters showed no evidence of harm, but they had half the rate ofpregnancy-related complications as women who took 400 IU of vitamin D everyday, says neonatologist and study co-researcher Carol L. Wagner, MD, of theMedical University of South Carolina.

Wagner acknowledges the recommendation may be controversial because veryhigh doses of vitamin D have long been believed to cause birth defects.

“Any doctor who hasn’t followed the literature may be wary of telling theirpatients to take 4,000 IU of vitamin D,” she says. “But there is no evidencethat vitamin D supplementation is toxic, even at levels above 10,000 IU.”

Fewer Complications With High Vitamin D Doses

Most prenatal vitamins have around 400 IU of vitamin D, and most healthgroups recommend taking no more than 2,000 IU of the vitamin in supplement formdaily. Wagner says it took months to get permission to do a study in whichpregnant women were given doses of the vitamin that were twice as high asthis.

The study included about 500 women in Charleston, S.C., who were in theirthird or fourth months of pregnancy. The women took 400 IU, 2,000 IU, or 4,000IU of vitamin D daily until they delivered.

Not surprisingly, women who took the highest doses of vitamin D were theleast likely to have deficient or insufficient blood levels of the vitamin, aswere their babies.

These women also had the lowest rate of pregnancy-related complications.

Compared to women who took 400 IU of vitamin D daily, those who took 4,000IU were half as likely to develop gestational diabetes, pregnancy-related highblood pressure, or preeclampsia, Wagner says. They were also less likely togive birth prematurely.

The research was presented over the weekend at the annual meeting of thePediatric Academic Societies in Vancouver, British Columbia.

Infants with very low vitamin D levels are at increased risk for soft bones,or rickets — a condition that is now rare in the U.S.

But over the last decade, more and more studies suggest that vitamin D alsoprotects against immune system disorders and other diseases, Wagner says.

Fortified milk and fatty fish are common food sources of vitamin D, but mostpeople get only a small fraction of the vitamin D they need through food,Wagner says. Instead, the body makes vitamin D from sunlight.

But even in sunny climates like Charleston, few people are now gettingadequate levels of vitamin D from sun exposure.

At the start of the study, deficient or insufficient levels of vitamin Dwere seen in 94% of the African-American women, 66% of Hispanic women, and 50%of white women who participated.

Vitamin D and Pregnancy: Is More Better?

University of Rochester professor of pediatrics Ruth Lawrence, MD, has beenrecording vitamin D levels in new mothers and their infants for three years.She did not take part in the new study.

Lawrence, who chairs the breastfeeding committee of the American Academy ofPediatrics, says exclusively breastfed babies whose mothers have low vitamin Dlevels and who don’t take vitamin supplements are most likely to bedeficient.

“It is clear that both for mothers and their babies, vitamin D levels arelow,” she tells WebMD. “This is true in northern areas like Rochester and insunny climates like Charleston.”

Lawrence sees no problem with the recommendation that women take 4,000 IU ofvitamin D daily during pregnancy, although she says the impact of high doses ofvitamin D on pregnancy-related complications remains to be proven.

“Four thousand IU may sound outrageous to some, but I believe it is reallynot unreasonable,” she says.

“We have been searching for the causes of preeclampsia and premature birthfor many years. It is reassuring that the risk of these complications are lowerfor women taking extra vitamin D, but it is premature to say it is thecause.”

The independent health policy group the Institute of Medicine recommends 200IU to 400 IU of vitamin D a day for everyone, including pregnant women, butthis recommendation is under review. Revised guidelines are expected late thissummer.

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