The NYPD says 76 protesters were arrested for blocking traffic in Manhattan Saturday afternoon.
The demonstrators staged a sit-in at the Microsoft store on Fifth avenue.
Organizers said they were demanding the tech company stop letting US immigration and customs enforcement use their technology.
The NYPD says 50 women and 26 men were arrested.
CNN has reached out to Microsoft for public comment on the arrests.
Last month, 100 people were arrested when the same coalition held a protest against “ice” on Manhattan’s west side highway.
The protest temporarily closing roadways to traffic.
In videos posted to Twitter, protesters could be seen in front of the Microsoft store holding signs and chanting “this is the price for business with ICE.”