Skin Aging Reversed in Lab Test

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Nov. 29, 2007 — Researchers say they’ve turned back the clock on aging skin– in mice, at least — and may be one step closer to unlocking the agingprocess.

“The implication is that the aging process is plastic and potentiallyamenable to intervention,” Stanford University assistant professor ofdermatology Howard Chang, MD, PhD, says in a news release.

But don’t kiss your wrinkles good-bye just yet. The technique hasn’t beentested in people and its long-term effects aren’t known.

Here’s how the experiment worked.

First, Chang’s team did some genetic detective work. They analyzed humantissue samples, looking for signs of gene activity related to aging.

A protein called NF-kB was “strongly associated with aging,”write the researchers. That protein appeared to control severalage-related genes.

Then, Chang and colleagues turned their attention to elderly mice. For twoweeks, the researchers slathered a chemical that blocks NF-kB activity in themice’s skin.

Those mice developed younger-looking skin that was about as thick as theskin of a newborn mouse.

“We found a pretty striking reversal to that of the young skin,”says Chang.

He adds that “the findings suggest that aging is not just a result ofwear and tear, but is also the consequence of a continually active geneticprogram that might be blocked for improving human health.”

But the study was short, and it’s not clear if blocking NF-kB is safe formice, let alone people.

The findings will appear in the Dec. 15 edition of Genes &Development.

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